Fig. 1. Peritoneal injection of DZNep reduced tumoral growth of CS in xenograft mice. CH2879 chondrosarcoma cell line was subcutaneously injected in the back of nude mice. When tumors were implanted and reached 300 mm³, DZNep was intraperitoneally injected three times per week (2 mg/kg) for 56 days. (A) Tumors were measured regularly by a caliper and tumoral volume calculated. (B-C) At the end of experiments, tumors were weighted and measured. Representative macroscopic views of the resected xenograft tumors of each group are shown. Data are expressed as means + SEM. N=9 and 7 for control and DZNep groups, respectively. *: p-value < 0.05; **: p-value < 0.01. (D) Proteins were extracted from tumors and PARP cleavage was analyzed by Western blot. Histograms represent the proportion of cleaved form of PARP on total PARP. Data are expressed as means + SEM (n=4).*: p-value < 0. 05.